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⚠️ MEDICAL DISCLAIMER: The information contained in this hub is for educational purposes only and is based on emerging clinical research (2024–2026). It does not constitute medical advice. Longevity protocols involve potent biological interventions. Always consult with a qualified healthcare professional before beginning any new supplementation regimen.

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Protocol Index

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PHASE 1: THE CLEARANCE PHASE (Steps 1 & 2: Fisetin, Spermidine)

🍓 Step 1: Fisetin (Senolytic Protocol)

• The Goal: Selective clearance of senescent "zombie" cells.
• The Protocol: The Mayo Clinic "Hit-and-Run" model. 20mg/kg of body weight for 2 consecutive days once every 4–8 weeks (For a 150lb adult, this is approximately 1,400mg per day).
• Critical Note: Must be taken with high-fat meals (avocado/olive oil) for absorption.
• 🟢 Vetted Source: Life Extension Bio-Fisetin (Amazon)
• 🔵 Vetted Source (International): Life Extension Bio-Fisetin (iHerb)

🌾 Step 2: Spermidine (Autophagy Induction)

• The Goal: Cellular recycling and cardiovascular protection.
• The Protocol: 1mg – 10mg daily. Synergizes with intermittent fasting.
• 🟢 Vetted Source (Availability Choice): Double Wood Spermidine (Amazon)] Note: Selected for consistent 10mg dosing and high-intent availability. Standard lab reference: SpermidineLIFE.
• 🔵 Vetted Source (Bioavailability Choice): Codeage Liposomal Spermidine (iHerb) Note: Vetted for 10mg delivery and enhanced liposomal absorption. Synergistic with N-A-D+ protocols.